The study's seventeen required advances are documented individually, but their relationships — which are hardest, which gate which, how they distribute across the three buckets and the development horizon — are easier to grasp side by side. This page is that side-by-side view. The four ◆ bottleneck advances are the critical-path constraints whose progress reshapes the whole programme.
Comparison table
Sort by any column; filter by bucket or to the named bottlenecks. Each code links to the full advance page.
| Code ⇅ | Advance | Bucket ⇅ | Risk ⇅ | Horizon ⇅ | Depends on |
|---|---|---|---|---|---|
| A1 | In vivo single-cell readoutReading cellular state at depth in a living patient. | A · Diagnostics | Moderate | 10–20y | A2, A5, B2 |
| A2 | Whole-body molecular mappingSingle-cell-resolution molecular state across the whole body. | A · Diagnostics | High | 20–35y | A1, A3, B2 ◆ bottleneck |
| A3 | Continuous temporal samplingDurable implantable sensing over clinically useful timescales. | A · Diagnostics | Low | 5–15y | A2 |
| A4 | Integrated state representationFusing heterogeneous data into one clinical picture with calibrated uncertainty. | A · Diagnostics | Low | 5–10y | B3 |
| A5 | Distributed pathogen & damage detectionEngineered and native detection of threats and tissue damage. | A · Diagnostics | Moderate | 15–25y | A1 |
| B1 | Complete variant effect predictionPredicting what genomic variants do, coding and non-coding. | B · Interpretation | Moderate to High | 10–40y | B3 |
| B2 | Real-time epigenomic state inferenceReading chromatin and methylation state in a living patient. | B · Interpretation | High | 20–30y | A1, A2 |
| B3 | Causal disease modellingCounterfactual modelling — the central scientific gap of the study. | B · Interpretation | Very High | 20–50y | A4, B1, B4 ◆ bottleneck |
| B4 | Personalised digital twinsPatient-specific simulations for intervention planning. | B · Interpretation | High | 15–30y | B3 |
| B5 | Continuous learning across patientsFederated, privacy-preserving model improvement over deployment. | B · Interpretation | Low | 5–10y | — |
| C1 | Multi-target coordinated interventionCoordinated, conditional, multi-payload therapeutic action. | C · Therapeutics | Moderate | 10–20y | — |
| C2 | Universal tissue accessDelivering therapy across protective barriers, including the BBB. | C · Therapeutics | High | 20–35y | — |
| C3 | Architectural tissue reconstructionRebuilding thick, vascularised tissue and organs. | C · Therapeutics | High | 25–40y | — |
| C4 | Neural reconnectionRestoring correct CNS wiring — the longest-horizon advance. | C · Therapeutics | Very High | 30–50y+ | — ◆ bottleneck |
| C5 | Bounded reversible molecular agentsTherapeutic agents that can be reliably switched off or reversed. | C · Therapeutics | Moderate | 10–20y | C6 |
| C6 | Multi-layered safety architectureDefence-in-depth that decides when to halt and guarantees override. | C · Therapeutics | Low to Moderate | 10–15y | C5 |
| C7 | Accelerated healing energy supplyFaster regeneration within the thermodynamic heat-dissipation ceiling. | C · Therapeutics | High | 20–35y | — ◆ bottleneck |
Dependency graph
Arrows run from a prerequisite advance to the advance that depends on it. The graph shows why the buckets cannot be pursued in isolation — interpretation advances depend on diagnostic ones, and the safety pair (C5, C6) is mutually reinforcing. Bottleneck advances are outlined in crimson. Nodes link to their detail pages.
Note: the graph shows direct dependencies declared on each advance page. Many softer relationships — shared techniques, gating by causal modelling, safety constraints — are discussed in the advance pages and the integration topic but omitted here to keep the critical path legible.
Development horizon
Each bar spans an advance's estimated time horizon, from earliest to latest plausible maturity, grouped by bucket. The pattern is the study's timeline argument in one picture: the low-risk advances cluster at the near end (the Phase I and early Phase II substrate), while the four bottlenecks — outlined in crimson — stretch toward the far end, with causal modelling and neural reconnection reaching out to fifty years. Bars link to their detail pages.
Horizons are conditional estimates, not commitments — they assume sustained investment and continued trajectories, and are revised at each decision gate. See the roadmap for how these horizons map onto the four phases.